niosh titanium dioxide manufacturers

Different dermal cell types have been reported to differ in their sensitivity to nano-sized TiO2 . Kiss et al. exposed human keratinocytes (HaCaT), human dermal fibroblast cells, sebaceous gland cells (SZ95) and primary human melanocytes to 9 nm-sized TiO2 particles at concentrations from 0.15 to 15 μg/cm2 for up to 4 days. The particles were detected in the cytoplasm and perinuclear region in fibroblasts and melanocytes, but not in kerati-nocytes or sebaceous cells. The uptake was associated with an increase in the intracellular Ca2+ concentration. A dose- and time-dependent decrease in cell proliferation was evident in all cell types, whereas in fibroblasts an increase in cell death via apoptosis has also been observed. Anatase TiO2 in 20–100 nm-sized form has been shown to be cytotoxic in mouse L929 fibroblasts. The decrease in cell viability was associated with an increase in the production of ROS and the depletion of glutathione. The particles were internalized and detected within lysosomes. In human keratinocytes exposed for 24 h to non-illuminated, 7 nm-sized anatase TiO2, a cluster analysis of the gene expression revealed that genes involved in the “inflammatory response” and “cell adhesion”, but not those involved in “oxidative stress” and “apoptosis”, were up-regulated. The results suggest that non-illuminated TiO2 particles have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes in extracellular matrix remodelling. In human keratinocytes, Kocbek et al. investigated the adverse effects of 25 nm-sized anatase TiO2 (5 and 10 μg/ml) after 3 months of exposure and found no changes in the cell growth and morphology, mitochondrial function and cell cycle distribution. The only change was a larger number of nanotubular intracellular connections in TiO2-exposed cells compared to non-exposed cells. Although the authors proposed that this change may indicate a cellular transformation, the significance of this finding is not clear. On the other hand, Dunford et al. studied the genotoxicity of UV-irradiated TiO2 extracted from sunscreen lotions, and reported severe damage to plasmid and nuclear DNA in human fibroblasts. Manitol (antioxidant) prevented DNA damage, implying that the genotoxicity was mediated by ROS.

...

By reducing processed foods in your diet, you can reduce the likelihood of not only eating titanium dioxide but eating other chemicals of concern, Faber said, noting that consumers can also call their elected representatives urging them to support increased food safety legislation and take action with organization alliances like Toxic Free Food FDA. America, once again, is falling behind the rest of the world when it comes to chemical safety.

...

In recent years, the demand for Lithopone B301 has seen a steady rise due to the growth in end-use industries. The construction industry, in particular, has driven demand due to its use in paint and coating formulations. Additionally, the increasing focus on eco-friendly alternatives in the plastics sector has further fueled the interest in this non-toxic pigment Additionally, the increasing focus on eco-friendly alternatives in the plastics sector has further fueled the interest in this non-toxic pigment Additionally, the increasing focus on eco-friendly alternatives in the plastics sector has further fueled the interest in this non-toxic pigment Additionally, the increasing focus on eco-friendly alternatives in the plastics sector has further fueled the interest in this non-toxic pigmentchina lithopone b301 quotes.

...

Rebecca Capua is an assistant conservator in the Paper Conservation Department at the Metropolitan Museum of Art since 2009. She received an MA in art history and an Advanced Certificate in art conservation from the Conservation Center, Institute of Fine Arts, New York University in 2007. Her primary area of research is on the materials of American artists of the late 19th and early 20th century. Address: The Sherman Fairchild Center for the Conservation of Works on Paper, Metropolitan Museum of Art, 1000 Fifth Avenue, New York, NY 10028. Email: rebecca.capua@metmuseum.org.

...